Dietary Iron Overload Abrogates Chemically-Induced Liver Cirrhosis in Rats

HFE Gene Mutations, Iron Overload and Cryptogenic Liver Cirrhosis

The diagnosis of cryptogenic cirrhosis is an exclusion diagnosis. It has become far less frequent over the last decades , but it still effects a significant number of patients. Many previously unknown chronic liver disease entities were described in the second half of the last century, including chronic viral hepatitis B, C and D, along with refined criteria for diagnosing autoimmune hepatitis ...

hfe gene mutations, iron overload and cryptogenic liver cirrhosis

Treatment of Experimental Dietary Cirrhosis of the Liver in Rats

Dietary cirrhosis of the liver was produced in 223 rats, and then therapy of the condition attempted. Administration of lipotropic factors (casein, methionine, choline) was followed not only by reduction of fat infiltration and by regeneration of hepatic parenchyma but, by a reduction of the degree of the fibrosis. In one group of rats, comparison of sections obtained by biopsy, before treatmen...

Secoisolariciresinol Diglucoside Abrogates Oxidative Stress-Induced Damage in Cardiac Iron Overload Condition

Cardiac iron overload is directly associated with cardiac dysfunction and can ultimately lead to heart failure. This study examined the effect of secoisolariciresinol diglucoside (SDG), a component of flaxseed, on iron overload induced cardiac damage by evaluating oxidative stress, inflammation and apoptosis in H9c2 cardiomyocytes. Cells were incubated with 50 μ5M iron for 24 hours and/or a 24 ...

Hemoglobin Andrew-Minneapolis: Hemolytic Erythrocytosis and Severe Iron Overload in Toxic Liver Cirrhosis

We report this case involving a 50-yr-old man of Central European descent who presented at our outpatient department with psoriasis. The known preexisting conditions in this case included alcohol-related toxic liver cirrhosis and untreated type 2 diabetes. The patient had an HbA1c level of 6.2%, which was determined during a routine diabetic monitoring visit. We also assessed HbA1c levels via H...